From 2019-2022, Interact for Health partnered with the Center for Public Health Systems Science at the Brown School at Washington University in St. Louis to conduct an evaluation of policy efforts in southwest Ohio to increase the minimum legal sales age of tobacco products from 18 to 21 (known as Tobacco 21) and related enforcement strategies. Findings and lessons learned illuminate the role local laws play in protecting youth in our communities, what it takes to move through the policymaking lifecycle, and the policy's impact - including a decrease of 27% in ease-of-access to tobacco products among Cincinnati youth from 2018 to 2022.